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What is Orthomolecular Nutrition?

Fernanda Rojas

Blog · Orthomolecular nutrition

Orthomolecular nutrition: what it is, benefits, and origin

Orthomolecular nutrition was born as a therapy to improve and restore people's optimal health levels. Discover below what it is, what its benefits are, and where it comes from.

5 min read · September 2026


01 · Origin

The origin of orthomolecular therapy

Orthomolecular medicine dates back to the 1960s, when the two-time Nobel Prize-winning scientist Linus Pauling observed that maintaining proper cell physiology and basic functions required certain molecules to be present in the body in specific amounts. That balance is what allows people to maintain a state of health.

In 1968, he named it in the journal Science: “orthomolecular,” from the Greek orthos, meaning correct.1

1954Nobel Prize in Chemistry2
1962Nobel Peace Prize2
1968Coins the term “orthomolecular”1

02 · What it is

Nutrition as the basis of treatment

Orthomolecular medicine considers nutrition to be the foundation of treatment. Therefore, it applies orthomolecular nutrition as a fundamental part of health recovery. To achieve this:

  1. 01
    It studies biochemical causesIt seeks the origin of imbalances at the cellular level, not just the symptoms.
  2. 02
    It applies laboratory testsIt measures the actual levels of nutrients and other markers in each person.
  3. 03
    It places relevance on the patient's clinical historyTheir history, symptoms, and lifestyle guide every decision.

03 · Benefits

A protocol for every person

Orthomolecular nutrition helps in the prevention of diseases. Once the patient's biochemistry has been studied, a personalized protocol is developed that combines nutrients, trace elements, amino acids, fatty acids, phytochemicals, and other micronutrients in the doses that each organism needs to restore altered functions.

This approach is based on a key concept: food can turn genes on or off. Nutrigenomics studies how nutrients influence the expression of our DNA without changing the genetic code.3 Proper nutrition helps protect the integrity of DNA, while a lack of micronutrients can promote DNA damage, a factor associated with serious illnesses.4

Proper nutrition helps protect the integrity of your DNA.


04 · What it uses

Natural substances for the body

Orthomolecular nutrition uses substances that exist naturally in the human body and in food, with good bioavailability. In addition to indicating a personalized meal plan, it is common to recommend oral nutritional supplements, such as:

Vitamins Minerals Trace elements Amino acids Fatty acids Prebiotics Probiotics Coenzymes

Important: intravenous administration of nutrients must be indicated and applied exclusively by medical professionals.

05 · Vitamins and minerals

Essential micronutrients

Micronutrients are essential for the proper functioning of the body. These are some of the vitamins that interact within orthomolecular nutrition and what they contribute to the body.5

VitaminWhat it doesBenefitsFound in
A What it doesParticipates in vision, cell growth, and immune function. BenefitsContributes to normal vision, maintaining healthy skin and mucous membranes, and proper immune function.6 Found inLiver, egg, carrot, squash
B6 What it doesInvolved in over 100 enzymatic reactions, especially in protein metabolism. BenefitsSupports the formation of neurotransmitters, nervous system function, and energy production.7 Found inFish, chicken, chickpeas, banana
C What it doesAntioxidant and cofactor in collagen formation. BenefitsProtects cells from oxidative stress, supports the immune system, wound healing, and iron absorption.8 Found inKiwi, citrus, bell pepper, broccoli
D What it doesRegulates calcium and phosphorus absorption. BenefitsContributes to maintaining strong bones and muscles and the proper functioning of the immune system.9 Found inSunlight, fatty fish, egg
E What it doesFat-soluble antioxidant that protects cell membranes. BenefitsHelps protect cells from oxidative damage and participates in immune function.10 Found inNuts, seeds, avocado, vegetable oils

Along with vitamins, minerals such as magnesium, zinc, and selenium complete the team: they are cofactors for hundreds of reactions that the body performs every day.

06 · In summary

Balance from the cell

Orthomolecular nutrition seeks to ensure that each person has the molecules they need, in the right amount, to balance the body naturally. At Ortomolecular Chile, we work with METAZOME™ dry liposomal technology to promote the bioavailability of each nutrient, and we are official distributors of Nordic Naturals in Chile.

Want to learn more? Read our guide What is orthomolecular nutrition?

Nutrients designed for your cells.

View products →

References

Sources consulted

  1. Pauling L. Orthomolecular psychiatry. Science. 1968;160(3825):265–271. doi:10.1126/science.160.3825.265
  2. The Nobel Prize. Linus Pauling – Facts. nobelprize.org
  3. Waterland RA, Jirtle RL. Transposable elements: targets for early nutritional effects on epigenetic gene regulation. Mol Cell Biol. 2003;23(15):5293–5300. doi:10.1128/MCB.23.15.5293-5300.2003
  4. Ames BN. DNA damage from micronutrient deficiencies is likely to be a major cause of cancer. Mutat Res. 2001;475(1–2):7–20. doi:10.1016/S0027-5107(01)00070-7
  5. National Institutes of Health, Office of Dietary Supplements. Dietary Supplement Fact Sheets. ods.od.nih.gov
  6. NIH ODS. Vitamin A and Carotenoids – Fact Sheet for Health Professionals. ods.od.nih.gov
  7. NIH ODS. Vitamin B6 – Fact Sheet for Health Professionals. ods.od.nih.gov
  8. NIH ODS. Vitamin C – Fact Sheet for Health Professionals. ods.od.nih.gov
  9. NIH ODS. Vitamin D – Fact Sheet for Health Professionals. ods.od.nih.gov
  10. NIH ODS. Vitamin E – Fact Sheet for Health Professionals. ods.od.nih.gov

This content is informational and does not replace the consultation, diagnosis, or treatment of a healthcare professional. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease.

5 comments

Les compré omega 3 líquido de 2840 mg

Cuánto tengo que tomar al día
Gracias

Paulina Foncea
Hola ! Yo estoy interesad@ en éste tratamiento, pero me imagino que debe de ser muy costoso, hay un Dr especialista en estas enfermedades aquí en las Islas Baleares España, y yo vivo en Barcelona. Me queda lejos y más gastos..lo recomendaré ..
Anónimo
Quiero para que sirve la vitamina d con k2 tengo tiroiditis de hashimoto me sirve tomarla.
jaquelina Estrada
Lástima que este conocimiento no se haga masivo y pueda estar al alcance de más personas y además costoso ,me encantaría acceder a ello pero soy pensionada y mi única alternativa son los medicamentos. Regalados por el estado , igual hablaré de esto a mis cercanos que tienen los medios económicos , muchas gracias
Leticia Zanetti
me parece muy interesante lo de la alimentacion Ortomolecular pero me falta q se indique el como puede uno acceder a una alimentacion de este tipo mas claramente , no tanto tecnisismo , es mi opinion gracias
JUAN

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