The exponential growth of the nutritional supplement industry in recent years is not an isolated phenomenon; it is the direct result of a perfect synergy between supply and demand.

More and more health professionals and their patients are showing a constant interest in prevention and general well-being, demanding therapeutic tools that go beyond the recommendation of pharmaceuticals.

In response, the market has seen constant innovation in nutritional supplements, both in the presentation formats (softgels, gummies, gels, sprays, powders, etc.) and in the implementation of mechanisms to ensure the quality of their absorption and effectiveness.

This constant innovation has reached a technological milestone with the development of liposomal supplements, an advanced solution designed to maximize the bioavailability of nutrients.

By encapsulating vitamins and minerals in tiny spheres of phospholipids (liposomes), the industry has managed to protect the active compounds from the digestive process, ensuring more efficient and direct absorption into the bloodstream.

This technical evolution not only raises the standard of the supplement but also responds to the increasing number of informed patients seeking real results backed by science.

They are nutrient delivery vehicles based on self-assembling spherical vesicles composed of one or more phospholipid bilayers, characterized by an amphipathic structure—meaning that liposomes are made of phospholipid molecules that have a hydrophilic (polar) head and hydrophobic (non-polar) tails.

In an aqueous medium, these molecules spontaneously orient themselves to form a bilayer that encloses an aqueous core, allowing for the co-encapsulation of water-soluble compounds in the center and lipophilic ones within the lipid matrix itself.

Unlike conventional supplementation, which relies on specific membrane transporters, liposomes can interact with cells through membrane fusion or receptor-mediated endocytosis. This allows the nutrient to avoid enzymatic and acid degradation in the upper gastrointestinal tract (stomach) and be absorbed directly in the small intestine.

By being absorbed in part through the lymphatic system, many liposomes manage to bypass first-pass hepatic metabolism, which drastically increases the plasma concentration of the nutrient.

Another point in their favor is that, because their composition is analogous to that of eukaryotic plasma membranes (generally using sunflower or soy lecithin phosphatidylcholine), they exhibit high biocompatibility, facilitating the delivery of the nutrient directly into the cellular cytosol.

Unfortunately, no. Just because a supplement claims to be liposomal does not ensure that its structure is stable or that it will perform its function correctly: It is key to choose dry liposomes rather than liquid ones.

Liposomes in liquid or traditional format exist in a suspension, meaning they are in constant motion and collide with one another. Over time, these liposomes break or stick together (fusion and aggregation phenomena), causing the nutrient to leak out before it is even ingested.

Furthermore, the constant presence of liquid facilitates the hydrolysis of phospholipid ester bonds, and exposure to dissolved oxygen promotes lipid peroxidation, which degrades both the capsule and the active ingredient (especially if it is sensitive, like Vitamin C or Glutathione).

The dry format, on the other hand, removes the liquid, trapping the liposomes in a solid matrix, which guarantees greater stability. The liposomes cannot collide or break; it is as if they were "frozen" and protected within a rigid shell. In liquid formats, it is common for a fraction of the nutrient to "leak" out of the liposome before being consumed, turning it into a low-absorption conventional supplement.

In dry formats, chemical deterioration reactions (such as hydrolysis) are halted, and the liposome ensures that the encapsulation rate remains constant until the moment of ingestion.

When ingested in powder or capsule form, the dry liposome is rehydrated in situ. This controlled rehydration can be designed so that the phospholipid vesicle remains intact against the pH gradient of the stomach, ensuring that membrane fusion occurs specifically with the target cells.

Through its METAZOME™ technology, which is a patented innovation by Molecules Biolabs representing the "next generation" of dry liposomal supplements.

This technology uses an oriented nanosphere approach to stabilize nutrients. Key scientific features include:

This technology solves the problem of degradation that many liquid liposomes suffer when exposed to temperature or oxygen, offering a powdered product that recovers its perfect liposomal structure upon contact with body fluids.

METAZOME™ technology is mainly applied to compounds that naturally have very low bioavailability or are extremely unstable when exposed to light, oxygen, or gastric pH.

• Glutathione: Considered the "master antioxidant," it is almost impossible to absorb through traditional oral routes because the stomach destroys it, which is why glutathione must be liposomal and also reduced. With METAZOME™, glutathione travels protected, achieving cellular levels previously reachable only via injections.

• Vitamin C: Although common, high doses often cause gastric irritation and are quickly eliminated through urine. Dry liposomal technology allows for total gastric tolerance and a much more prolonged presence in the blood.

• Coenzyme Q10: A crucial molecule for cellular energy (mitochondria), it is very "heavy" and difficult for the intestine to process. Dry liposomal encapsulation facilitates its direct passage into the bloodstream.

• Magnesium: Being encapsulated, it avoids the laxative effect that some people experience with conventional magnesium salts, improving direct delivery to the nervous and muscular systems.

The choice of a supplement should not be based solely on the amount of milligrams stated on the label, but on the organism's actual capacity to absorb them.

METAZOME™ technology represents the evolution in supplementation, eliminating the instabilities of liquid formats and the limitations of traditional capsules.

By preferring supplements with this technology, patients not only acquire a product, but a guarantee of cellular delivery, optimizing their health investment through superior purity and bioavailability.

Mercola J. (2025). Targeted nanoliposomal nutrient delivery for human health. World journal of gastrointestinal pharmacology and therapeutics, 16(4), 111502. https://doi.org/10.4292/wjgpt.v16.i4.111502

https://www.sciencedirect.com/science/article/pii/S2772566925003398#:~:text=Abstract,utilization%20in%20the%20food%20sector.

https://pubs.acs.org/doi/10.1021/acsnutrsci.5c00002#:~:text=After%20that%2C%20vitamin%20C%20(70,Figure%201.